One of my coworkers had some issues running Outlook 2007. When she started Outlook, there was an error saying “Cannot start Microsoft Office Outlook. Cannot open the Outlook window.”. I tried running Outlook in safemode with no success.

The Problem:

Usually it happens when the file that maintains the navigation pane is corrupted. The file name is “Profilename.xml“, where profilename is the user’s outlook profile name.

This is the navigation pane:

The Solution:

In order to fix the Outlook error: “Cannot start Microsoft Office Outlook. Cannot open the Outlook window”, all you have to do, is to reset the navigation pane’s settings:

Click Start + R (Run) -> type Outlook.exe /resetnavpane -> Enter.

Enjoy!